Personalised Probiotics
Did you know that more than 50 strains of probiotics have been discovered, and everyone responds to them differently? We can identify the strain that boosts your immunity the best.
WHAT ARE PROBIOTICS
Probiotics are microorganisms residing in our guts that communicate with various immune cells. Hence, they play a significant role in modulating and boosting our immunity when the microflora is balanced. Moreover, Given this, probiotics are often regarded as the 'medicine with no harm,' carrying the potential to alleviate a wide range of physical and mental conditions.
THE GUT-BRAIN AXIS
Mounting evidence indicates that microbial communities in the intestines can regulate brain development, mood, and cognitive function through bidirectional signalling between the gut and the brain. The immune system serves as an essential coordinator of these interactions. Consequently, probiotics, or beneficial microbes, are being considered as promising therapeutic targets to modulate behaviour and brain development by adjusting the gut microbiota.
Adopted from SALVO-ROMERO et. al. LymphoSign 2020
Adopted from CHRISTOFORI et. al. Front Immunol 2021
HOW DO PROBIOTICS COMMUNICATE WITH IMMUNE SYSTEM
Probiotics in the gut lumen engage in crosstalk with sentinel cells such as dendritic cell and macrophage, in the lymphatic tube. Subsequently, they activate naive T cells, leading to a series of differentiations into various T cells isotopes that secret different cytokines.
Overactivation of Th1 cells can result in excessive IFNγ production, leading to chronic inflammation and anti-immune problems. On the other hand, overactivated Treg cells producing too much IL-10 can lead to allergies. This imbalance can be corrected at its source by providing a corresponding probiotic strain with the strongest activation activity.
WHY DO WE NEED THE PERSONALISED PROBIOTICS
Every individual's genomic DNA carries subtle differences that do not affect our basic biological functions, knowing as "single-nucleotide polymorphisms", or SNPs. It's believed that SNPs contribute to differential personal traits, including susceptibility to a wide rage of diseases. Similarly, each person responds differently to probiotic strains. The specific strain capable of eliciting the optimal secretion of particular cytokines from our immune cells is the most beneficial to us. Through a matching process, we can identify which probiotic strain is capable of balancing and boosting our immunity the most.
THE REAL PERSONALISED PROBIOTICS MATCHING
We employ the state-of-the-art proprietary microfluidic chips in the personalised probiotics matching process. These chips offer higher accuracy, reduce human error, lower sample and reagent consumption, and enhance efficiency. The matching process only takes 7 days to unveil the cytokine secretion profiles generated by one's immune cells in response to 6~10 of our patented probiotic strains. Based on an individual's current needs, we select the most suitable strain for them.
SELECTED SCIENTIFIC READINGS
1. Ho et.al. Daily intake of probiotics with high IFN-gamma/IL-10 ratio increases the cytotoxicity of human natural killer cells: a personalized probiotic approach J Immunol Res 2014
2. Pique et.al. Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview Int J Mol Sci 2019
3. Salvo-Romero et.al. Microbiota-immune interactions: from gut to brain LymphoSign J 2020
4. Cristofori et.al. Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body Front Immunol 2021
5. Liu et.al. Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics Front Nutr 2021
6. Hashemi et.al. The effect of probiotics on immune responses and their therapeutic application: A new treatment option for multiple sclerosis Biomed Pharmacother 2023
7. Mazziotta et.al. Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health Cells 2023
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